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March 27, 2013

Hyper-cleanliness may make us prone to getting sick

A growing body of evidence suggests that all the antibacterial-wiping, germ-killing cleanliness of the developed world may actually be making us more prone to getting sick — and that a little more dirt might help us stay healthier in the long run.

The idea, known as the hygiene hypothesis, was first proposed in 1989 by epidemiologist David P. Strachen, who analyzed data from 17,414 British children and found that those who had grown up with more siblings (and presumably more germs) were less likely to have allergies and eczema. Since then, the theory has been cited as a possible explanation for everything from multiple sclerosis to hay fever and autism. But its particulars aren't so clean and clear.

Here's what researchers do know: Our immune systems need bugs. They rely on early encounters with germs to learn how to protect our bodies.

"Bacteria, fungi, lots of these things we think of as bad — they're all part of our environment, and we evolved to live with them," says Michael Zasloff, an immunologist and physician at MedStar Georgetown University Hospital. Through exposure to these microbes early in life, your immune system learns what's harmful and what isn't, he says, and that readies the immune responses you'll have for the rest of your life.

"The body has got to know friend from foe," Zasloff says. If your body learns that a specific microbe or substance — any antigen, or visitor to the body — is a foe, it will send immune system cells to destroy it. If it recognizes the antigen as a friend, the immune system will leave it alone. "Exposure tells the immune system, 'These are the things you're going to run into all the time, so you don't need to worry about them.' "

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