Lester was pulled with the bases loaded in the sixth, but Junichi Tazawa got Coco Crisp to fly out.
Josh Donaldson’s RBI single made it 6-4 and Young’s second homer cut it to one in the eighth.
The Athletics had jumped ahead with three runs against Lester in the fourth on Young’s homer that caromed off a billboard above the Green Monster seats, but Boston tied it with three in the bottom of the inning.
Ortiz, back in the lineup after getting Tuesday off, doubled leading off and scored on Napoli’s double. Jonny Gomes walked and, one out later, Drew tripled into the right-field corner.
NOTES: Anderson had left his previous start with a sprained right ankle. ... Oakland manager Bob Melvin said he kept Josh Reddick out of the starting lineup with a tough lefty going now that it looks like the outfielder’s worked out of a slump. Reddick was 2 for 4 in each of the first two games after going just 3 for 37 in the previous 10. Reddick struck out pinch hitting. ... Boston recalled RHP Daniel Bard from Double-A Portland before the game and optioned RHP Steven Wright to Triple-A Pawtucket. ... The Red Sox again honored members of the Watertown police department. Members stood on top of both dugouts, got a big ovation from fans and both teams. ... Home plate umpire Jerry Layne left the game after being hit on the left hand by a foul tip in the third. Second base ump Mike Estabrook took over behind the plate. ... Anderson was 5-2 with a 2.70 ERA in eight starts against Boston. ... A fan was taken from the stands on a stretcher in the ninth.