Luck followed with a 43-yard scoring pass to T.Y. Hilton, the second of the game to the fellow rookie. But the Patriots responded with touchdown runs of 3 yards by Stevan Ridley and 4 yards by Shane Vereen.
The game began with touchdowns on the first three series — a 1-yard run by Delone Carter of the Colts, a 4-yard pass from Brady to Gronkowski and a 14-yard pass from Luck to Hilton.
Stephen Gostkowski then missed a 36-yard field goal attempt for the Patriots.
But their fortunes changed four plays later when Edelman brought a punt back for a touchdown for the third time in his career after the defense forced Luck into a three-and-out. And just three plays and 61 seconds after that, the Patriots scored again on Talib’s touchdown as the Patriots took the lead for good 21-14 with 10:59 left in the second quarter.
The catch was an easy one — Luck threw the ball high over Reggie Wayne’s head — but the run was exceptional as Talib cut from the right side of the field all the way to the left, eluding numerous Colts.
The Patriots obtained Talib from Tampa Bay before last Sunday’s 37-31 win over Buffalo. But he sat that one out to complete a four-game suspension for violating the NFL policy on performance-enhancing substances.
Former Patriots kicker Adam Vinatieri, booed often in a stadium where he once was adored, cut the lead to 21-17 on a 47-yard field goal 5:46 before intermission.