They trailed 31-3 early in the third quarter before scoring 28 points in just over 14 minutes, a stunning comeback that tied the game at 31 with 6:43 left.
But the 49ers took the lead for good after a long kickoff return followed by a 38-yard TD pass from Colin Kaepernick to Michael Crabtree.
“It was definitely pretty bizarre,” Patriots receiver Wes Welker said. “It’s just one of those games that kind of didn’t go our way, went our way and then didn’t. We’ve just got to move on and look forward to the next week.”
And avoid something that hasn’t happened in more than 10 years.